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Biomarker Colocalization

The ExoView™ platform provides the ability to measure up to 4 markers on a single extracellular vesicles.

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Key Features of Fluorescent Measurements:

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fluorescence

3 color fluorescence. Single binding event sensitivities mean that even the smallest EVs are detectable

Biomarker colocalization

Measure up to 4 proteins per EV. Measure EV sub-populations through relative protein expression

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EV CARGO

Probe for luminal EV proteins and cargo in single EVs

 

 

Single binding event sensitivities

Measure even the smallest EVs

with confidence

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3 COLOR FLUORESCENCE

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Multiplexed binding and counter-staining of single EVs

The ExoView™ platform measures 3 color fluorescence on single extracellular vesicles which are bound to the ExoView™ microarray chip.

Extracellular vesicles are captured from solution without purification and bound to one of 6 different capture antibodies (plus control) on the surface of the ExoView™ chip. Secondary fluorescent antibodies can then be added and up to 3 colors can be measured simultaneously.

Single binding event sensitivities mean that even poorly expressed proteins on the smallest of extracellular vesicles are detectable through the high sensitivity of ExoView™.

 

 Colocalize up to 4 markers per EV

Generate color coded heat maps of protein distribution on single EVs

Simultaneously measure size and count information

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Quantify the degree of biomarker colocalization on single EVs

 

 

Probe for luminal proteins via permeablization of captured EVs

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Fluorescent measurement of EVs made simple

 

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