For Research Use Only. Not for use in diagnostic procedures.

For Research Use Only. Not for use in diagnostic procedures.


ExoView™ R100

A step forward in characterization capabilities within the extracellular vesicles (EV) field. The fully automated platform provides multi-level and comprehensive EV measurements for particle size analysis, EV count, EV phenotype, and biomarker colocalization. The ExoView™ platform provides previously unattainable information in a single and bias free sample workflow.

ExoView™ works without the need for sample purification, and brings the researcher one step closer to analyzing a sample in its natural state. ExoView™ R100 is an affinity based technology that allows specific populations of EVs to bind in a multiplexed manner to a functional ExoView™ chip. The fully automated instrument can measure 9 samples automatically, direct from sample, saving cost, time, and reducing purification biases.

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ExoView™ R100 Key Features:

 
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EV SIZE

Measure the size of EVs down to 50nm in interferometric imaging mode

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EV COUNT

Count the number of EVs expressing specific surface markers

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EV CARGO

Probe for EV luminal proteins and cargo

 
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PURIFICATION NOT REQUIRED

35µl of diluted plasma or conditioned media can be measured directly without the need for sample purification

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Streamlined workflow

Automated analysis of up to 9 samples with single button sample analysis

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fluorescence

Interrogate biomarker colocalization through 3 color fluorescence measurements with single binding event sensitivity

 

 
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Measure up to 4 markers on single EVs:

The ExoView™ platform provides the ability to measure up to 4 markers on single EVs. The multiplexed array allows up to 6 markers to be probed in parallel through binding of the EVs to an ExoView™ chip. The addition of fluorescent antibodies provides the ability to probe for an additional 3 markers with single fluorescent antibody sensitivity.

The image shows the binding of single EVs to a CD9 antibody spot, interferometic imaging measurements are show to the left and 3 color fluorescence on the right. A heat map of marker expression on single EVs can be generated (external or luminal proteins), while simultaneously measuring their size and count.

Capture Antibody Marker 1 Marker 2 Marker 3
Marker 4 Marker 5 Marker 6
Fluorescent Antibody A A A A A A
B B B B B B
C C C C C C
 

 
 

Specifications:

Minimum Particle Size Scatter

50nm


Concentration Linearity

5x105 to 1x108 particles/mL


Fluorescence Sensitivity

Better than 10 fluorescein equivalents


Excitation Wavelengths

410nm (interferometry)
488nm (fluoresence)
555nm (fluoresence)
640nm (fluoresence)

 
 

For Research Use Only. Not for use in diagnostic procedures.